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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
29/01/2020 |
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Actualizado : |
29/01/2020 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
CARVALHO, F.E.; ESPIGOLAN, R.; BERTON, M.P.; NETO, J.B.S.; SILVA, R.P.; GRIGOLETTO, L.; SILVA, R.M.O.; FERRAZ, J.B.S.; ELER, J.P.; AGUILAR, I.; LÔBO, R.B.; BALDI, F. |
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Afiliación : |
F.E.CARVALHO, Departament of Veterinary Medicine, College of Animal Science and Food Engineer, University of São Paulo (USP), Pirassununga/SP, Brazil; R. ESPIGOLAN, Departament of Veterinary Medicine, College of Animal Science and Food Engineer, University of São Paulo (USP), Pirassununga/SP, Brazil; M. P. BERTON, Departament of Animal Science, College of Agricultural and Veterinarian Sciences, São Paulo State University (UNESP), Jaboticabal/SP, Brazil; J. B. S. NETO, Departament of Animal Science, College of Agricultural and Veterinarian Sciences, São Paulo State University (UNESP), Jaboticabal/SP, Brazil; R. P. SILVA, Departament of Veterinary Medicine, College of Animal Science and Food Engineer, University of São Paulo (USP), Pirassununga/SP, Brazil; L. GRIGOLETTO, Departament of Veterinary Medicine, College of Animal Science and Food Engineer, University of São Paulo (USP), Pirassununga/SP, Brazil; R. M. O. SILVA, Zoetis, 1240 Dr. Chucri Zaidan Street, Edifício Morumbi Corporate, Diamond Tower, 4th floor, São Paulo, SP, Brazil; J. B. S. FERRAZ, Departament of Veterinary Medicine, College of Animal Science and Food Engineer, University of São Paulo (USP), Pirassununga/SP, Brazil; J. P . ELER, Departament of Veterinary Medicine, College of Animal Science and Food Engineer, University of São Paulo (USP), Pirassununga/SP, Brazil; IGNACIO AGUILAR GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; LÔBO, R.B., Nacional Association of Breeders and Researchers (ANCP), Ribeirão Preto, SP, Brazil; F. BALDI, Departament of Animal Science, College of Agricultural and Veterinarian Sciences, São Paulo State University (UNESP), Jaboticabal/SP, Brazil. |
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Título : |
Genome-wide association study and predictive ability for growth traits in Nellore cattle. |
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Fecha de publicación : |
2020 |
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Fuente / Imprenta : |
Livestock Science, January 2020, Volume 231, Article number 103861. OPEN ACCESS. Doi: https://doi.org/10.1016/j.livsci.2019.103861 |
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ISSN : |
1871-1413 |
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DOI : |
10.1016/j.livsci.2019.103861 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 25 June 2019 / Revised 29 October 2019 / Accepted 4 November 2019 / Available online 6 November 2019.
Funding information: F.E. CARVALHO received a scholarship from Coordinating for the Improvement of Higher Education Personnel (CAPES) in conjunction with the Postgraduate Program on Zootecnia, Universidade de São Paulo, Faculdade de Zootecnia e Engenharia de Alimentos (FZEA, USP). To National Association of Breeders and Researchers (ANCP, Ribeirão Preto-SP, Brazil). To Fapesp, ( Sao Paulo Research Foundation , grants #2016/222751-6 #2017/10493-5 ). F.B held productivity research fellowships from The Brazilian National Council for Scientific and Technological Development (CNPQ). |
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Contenido : |
ABSTRACT.
This study aimed to identify genomic regions influencing growth traits in Nellore cattle and evaluate the predictive ability of each trait based on results obtained from single-step genome-wide association analyzes (ssGWAS) considering different single nucleotide polymorphims (SNP) densities of markers. The National Association of Breeders and Researchers provided the dataset, from eighteen Nellore herds participating of the Nellore Brazilian breeding program. The traits birth weight (BW), adjusted weight at 210 (W210) and at 450 (W450) days of age and adult cow weight (ACW) were considered. A total of 963 animals, genotyped using the Illumina BovineHD BeadChip, were used as a reference population to impute genotypes of 7,689 animals, genotyped in low-density panel. Genotype imputation was performed using the FImpute 2.2 software. The ssGWAS was used to identify genomic regions associated to growth traits. Several genes in enrichment analysis were related to muscle and adipose tissue development and metabolism, feed efficiency, milk composition and maternal behavior. The predictive ability varied from low (0.10) to moderate (0.68). The predictive ability and bias for both panels were similar for all traits. The results found in this study should improve the understanding of genetic and physiologic mechanism associated with growth traits. However, the association of these results with other approaches, like system biologic and other omics information should improve the identification of causative genetic variants in growth traits in indicine cattle.
© 2019 Elsevier B.V. MenosABSTRACT.
This study aimed to identify genomic regions influencing growth traits in Nellore cattle and evaluate the predictive ability of each trait based on results obtained from single-step genome-wide association analyzes (ssGWAS) considering different single nucleotide polymorphims (SNP) densities of markers. The National Association of Breeders and Researchers provided the dataset, from eighteen Nellore herds participating of the Nellore Brazilian breeding program. The traits birth weight (BW), adjusted weight at 210 (W210) and at 450 (W450) days of age and adult cow weight (ACW) were considered. A total of 963 animals, genotyped using the Illumina BovineHD BeadChip, were used as a reference population to impute genotypes of 7,689 animals, genotyped in low-density panel. Genotype imputation was performed using the FImpute 2.2 software. The ssGWAS was used to identify genomic regions associated to growth traits. Several genes in enrichment analysis were related to muscle and adipose tissue development and metabolism, feed efficiency, milk composition and maternal behavior. The predictive ability varied from low (0.10) to moderate (0.68). The predictive ability and bias for both panels were similar for all traits. The results found in this study should improve the understanding of genetic and physiologic mechanism associated with growth traits. However, the association of these results with other approaches, like system biologic and other omics information should improve ... Presentar Todo |
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Palabras claves : |
BEEF CATTLE; Genomic; Predictive ability; Single nucleotide polymosphism. |
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Asunto categoría : |
L10 Genética y mejoramiento animal |
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URL : |
https://www.sciencedirect.com/science/article/pii/S1871141319308935/pdfft?md5=2a644d20a870893fa10662e7fb7ecf40&pid=1-s2.0-S1871141319308935-main.pdf
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Marc : |
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024 7 $a10.1016/j.livsci.2019.103861$2DOI
100 1 $aCARVALHO, F.E.
245 $aGenome-wide association study and predictive ability for growth traits in Nellore cattle.$h[electronic resource]
260 $c2020
500 $aArticle history: Received 25 June 2019 / Revised 29 October 2019 / Accepted 4 November 2019 / Available online 6 November 2019. Funding information: F.E. CARVALHO received a scholarship from Coordinating for the Improvement of Higher Education Personnel (CAPES) in conjunction with the Postgraduate Program on Zootecnia, Universidade de São Paulo, Faculdade de Zootecnia e Engenharia de Alimentos (FZEA, USP). To National Association of Breeders and Researchers (ANCP, Ribeirão Preto-SP, Brazil). To Fapesp, ( Sao Paulo Research Foundation , grants #2016/222751-6 #2017/10493-5 ). F.B held productivity research fellowships from The Brazilian National Council for Scientific and Technological Development (CNPQ).
520 $aABSTRACT. This study aimed to identify genomic regions influencing growth traits in Nellore cattle and evaluate the predictive ability of each trait based on results obtained from single-step genome-wide association analyzes (ssGWAS) considering different single nucleotide polymorphims (SNP) densities of markers. The National Association of Breeders and Researchers provided the dataset, from eighteen Nellore herds participating of the Nellore Brazilian breeding program. The traits birth weight (BW), adjusted weight at 210 (W210) and at 450 (W450) days of age and adult cow weight (ACW) were considered. A total of 963 animals, genotyped using the Illumina BovineHD BeadChip, were used as a reference population to impute genotypes of 7,689 animals, genotyped in low-density panel. Genotype imputation was performed using the FImpute 2.2 software. The ssGWAS was used to identify genomic regions associated to growth traits. Several genes in enrichment analysis were related to muscle and adipose tissue development and metabolism, feed efficiency, milk composition and maternal behavior. The predictive ability varied from low (0.10) to moderate (0.68). The predictive ability and bias for both panels were similar for all traits. The results found in this study should improve the understanding of genetic and physiologic mechanism associated with growth traits. However, the association of these results with other approaches, like system biologic and other omics information should improve the identification of causative genetic variants in growth traits in indicine cattle. © 2019 Elsevier B.V.
653 $aBEEF CATTLE
653 $aGenomic
653 $aPredictive ability
653 $aSingle nucleotide polymosphism
700 1 $aESPIGOLAN, R.
700 1 $aBERTON, M.P.
700 1 $aNETO, J.B.S.
700 1 $aSILVA, R.P.
700 1 $aGRIGOLETTO, L.
700 1 $aSILVA, R.M.O.
700 1 $aFERRAZ, J.B.S.
700 1 $aELER, J.P.
700 1 $aAGUILAR, I.
700 1 $aLÔBO, R.B.
700 1 $aBALDI, F.
773 $tLivestock Science, January 2020, Volume 231, Article number 103861. OPEN ACCESS. Doi: https://doi.org/10.1016/j.livsci.2019.103861
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INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
26/03/2022 |
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Actualizado : |
26/03/2022 |
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Tipo de producción científica : |
Abstracts/Resúmenes |
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Autor : |
CIUFFO, C.; ARÉVALO, A.P.; GARCIA, F.; PERDOMO, T.; CRISPO, M.; GIANNITTI, F.; BUSCHIAZZO, A.; ZARANTONELLI, L. |
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Afiliación : |
CAMILA CIUFFO, Unidad Mixta UMPI, Institut Pasteur Montevideo + INIA, Montevideo, Uruguay; ANA PAULA ARÉVALO, Unidad de Biotecnología en Animales de Laboratorio, Institut Pasteur de Montevideo, Montevideo, Uruguay.; FEDERICO GARCIA SUAREZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; TERESITA YISELL PERDOMO TORRES, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARTINA CRISPO, Unidad de Biotecnología en Animales de Laboratorio, Institut Pasteur de Montevideo, Montevideo, Uruguay.; FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ALEJANDRO BUSCHIAZZO, Laboratorio de Microbiología Molecular y Estructural, Institut Pasteur de Montevideo, Montevideo, Uruguay.; LETICIA ZARANTONELLI, Unidad Mixta UMPI, Institut Pasteur Montevideo + INIA, Montevideo, Uruguay; Laboratorio de Microbiología Molecular y Estructural, Institut Pasteur de Montevideo, Montevideo, Uruguay. |
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Título : |
Estudio de la capacidad infectiva, colonización renal e inmunogenicidad de Leptospira interrogans serogrupo Pomona serovar Kennewicki en un modelo murino sub-letal y crónico. [abstract]. |
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Complemento del título : |
Sub-área 4: Patogenia, virulencia y resistencia. |
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Fecha de publicación : |
2021 |
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Fuente / Imprenta : |
In: Anais III Consensos Latinoamericanos em Leptospirose Animal. Nov 30-Dic 02, 2021 (evento online). |
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Idioma : |
Español |
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Contenido : |
En Uruguay, Leptospira interrogans sg Pomona sv Kennewicki es la variante más frecuentemente aislada en bovinos. También ha sido identificada en brotes de leptospirosis en ovinos y en jabalíes (Sus scrofa), así como en humanos, lo cual sugiere fuertemente la transmisión zoonótica. El objetivo de este estudio fue evaluar atributos de virulencia de L. interrogans sg Pomona sv Kennewicki en un modelo murino, mimetizando una vía de infección natural. |
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Palabras claves : |
Leptospira interrogans; PLATAFORMA DE SALUD ANIMAL. |
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Thesagro : |
LEPTOSPIROSIS. |
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Asunto categoría : |
L73 Enfermedades de los animales |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/16360/1/Estudio-de-la-capacidad-infectiva-colonizacion-renal-e-inmunogenicidad-de-Leptospira-interrogans-abstract-2021.pdf
https://www.faculdadeinove.me/3clla/edicoes/iiiclla/anais
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Marc : |
LEADER 01295nam a2200229 a 4500
001 1062919
005 2022-03-26
008 2021 bl uuuu u01u1 u #d
100 1 $aCIUFFO, C.
245 $aEstudio de la capacidad infectiva, colonización renal e inmunogenicidad de Leptospira interrogans serogrupo Pomona serovar Kennewicki en un modelo murino sub-letal y crónico. [abstract].$h[electronic resource]
260 $aIn: Anais III Consensos Latinoamericanos em Leptospirose Animal. Nov 30-Dic 02, 2021 (evento online).$c2021
520 $aEn Uruguay, Leptospira interrogans sg Pomona sv Kennewicki es la variante más frecuentemente aislada en bovinos. También ha sido identificada en brotes de leptospirosis en ovinos y en jabalíes (Sus scrofa), así como en humanos, lo cual sugiere fuertemente la transmisión zoonótica. El objetivo de este estudio fue evaluar atributos de virulencia de L. interrogans sg Pomona sv Kennewicki en un modelo murino, mimetizando una vía de infección natural.
650 $aLEPTOSPIROSIS
653 $aLeptospira interrogans
653 $aPLATAFORMA DE SALUD ANIMAL
700 1 $aARÉVALO, A.P.
700 1 $aGARCIA, F.
700 1 $aPERDOMO, T.
700 1 $aCRISPO, M.
700 1 $aGIANNITTI, F.
700 1 $aBUSCHIAZZO, A.
700 1 $aZARANTONELLI, L.
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